Side Effects of Gabapentin and Pregabalin in Long-Term Use Introduction Gabapentin and pregabalin are among the most commonly prescribed medications for diabetic neuropathy and other forms of chronic nerve pain. These drugs, classified as gabapentinoids, work by modulating nerve activity and reducing pain signals to the brain. Initially marketed as safe alternatives to opioids, they
Why Painkillers and Anticonvulsants Fail in Chronic Diabetic Neuropathy Introduction Chronic diabetic neuropathy is a persistent and often worsening condition that affects millions of diabetics worldwide. Burning, stabbing, or electric-shock-like pain in the limbs is one of the most disturbing symptoms—and it’s usually addressed with painkillers or anticonvulsants. While these medications may offer short-term relief,
Progression of Diabetic Neuropathy Diseases: A Silent March of Nerve Damage Introduction Diabetic neuropathy is often misunderstood as a singular condition. In truth, it is a spectrum of progressive nerve disorders caused by the long-term effects of high blood sugar on the nervous system. What starts as mild numbness in the feet can slowly evolve
Correcting Microcirculation to Improve Nerve Pain: The Key to Reversing Neuropathy at Its Root Introduction In diabetic neuropathy, the focus often remains on blood sugar and nerve pain. But one crucial piece of the puzzle is frequently overlooked: microcirculation. The smallest blood vessels—capillaries, arterioles, and venules—form a vast network that supplies oxygen and nutrients to
